To maximize the fat-burning effects, try taking Phen-Free about one hour prior to exercise, especially cardiovascular exercise, performed first thing in the morning. You can also take 1 dose 30 minutes before a meal. Since this is a powerful metabolic support formula and contains some potent ingredients like caffeine and synephrine, it's best to stick with the recommendation of taking two to four capsules daily, 30 minutes before meals and/or exercise. Remember, if you have hypertension, heart problems, nervous disorders, are pregnant, or have any other medical condition, please consult your physician before using Phen-Free.

Phen-Free was designed to be similar to the popular thermogenic combination of caffeine, ephedrine, and aspirin. Some research suggests this combination increases fat burning and boosts metabolic rate.

With Phen-Free, EAS researchers made some modifications to create this state-of-the-art thermogenic product. One of the modifications was to use Citrus aurantium standardized to six percent synephrine instead of ephedrine. Citrus aurantium, ephedrine's "calmer" chemical cousin, offers many of the metabolic-enhancing effects of ephedrine. The other ingredients, including yohimbe, cordyceps, L-tyrosine, St. John's wort, synephrine, and cayenne pepper powder, may work together to create the powerful thermogenic effects of this product.

Like ephedrine, synephrine is an adrenergic amine that is extracted from the Chinese fruit zhishi, also known as Citrus aurantium, or bitter orange. Both ephedrine and synephrine may enhance metabolic rate, increase fat burning, and spare muscle protein. However, people who use synephrine typically experience very little, if any, of the "agitation" associated with ephedrine use, probably because synephrine causes less central nervous system stimulation.

Synephrine is distributed efficiently to other tissues in the body, including muscle and fat cells. There, like ephedrine, it stimulates both alpha and beta adrenoreceptors. Ongoing research indicates synephrine may be more thermogenic (increasing resting metabolic rate) but cause less stimulation to the heart rate and blood pressure than ephedrine. Research also indicates that synephrine is safe, with no serious side effects reported in laboratory animals at doses as high as 10 grams per kilogram body weight (4.5 grams/pound).